1. Which dosage form provides zero-order release kinetics, maintaining constant drug plasma levels over time?

2. A patient weighing 65 kg requires gentamicin 5 mg/kg/day IV divided every 8 hours. The available concentration is 40 mg/mL. How many milliliters should be administered per dose?

3. Which sterilization method is MOST appropriate for heat-labile ophthalmic solutions?

4. Which drug exhibits polymorphism where the metastable form has higher solubility but converts to stable form during storage?

5. A prescription calls for "qs ad 30 mL" of a suspension. What does "qs ad" mean?

6. Which preservative is commonly used in multidose ophthalmic preparations at 0.01% concentration?

7. Which factor MOST significantly affects the bioavailability of a weakly acidic drug administered orally?

8. A 5-year-old child (weight 18 kg) requires oral rehydration solution containing 75 mEq/L sodium. How many milliequivalents of sodium are in a 200 mL dose?

9. Which pharmaceutical calculation principle is used to determine the amount of active ingredient when mixing two solutions of different concentrations?

10. Which excipient serves as both a binder and a disintegrant in tablet manufacturing?

11. A pharmacist must prepare 500 mL of 1:5000 potassium permanganate solution. How many milligrams of potassium permanganate are required?

12. Which stability-indicating parameter is MOST critical for monitoring degradation of aspirin tablets during storage?

13. Which route of administration completely avoids first-pass hepatic metabolism?

14. A prescription requires 30 g of 2% miconazole cream. The pharmacy has 10 g tubes of 2% cream. How many tubes are needed to compound the prescription?

15. A 70 kg adult requires dopamine infusion at 5 mcg/kg/min. The prepared solution contains 400 mg dopamine in 250 mL D5W. What is the infusion rate in mL/hour?

16. Which quality control test ensures uniformity of weight in uncoated tablets?